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Almul
Tiamulin Fumarate Soluble Powder 45%
Active Ingredient
Tiamulin Fumarate
Description
This product is a white or off-white powder.
Pharmacological Properties
Pharmacodynamics
Tiamulin belongs to the pleuromutilin class of antibiotics and exhibits bactericidal activity against susceptible bacteria at high concentrations. It exerts its antibacterial effect by binding to the 50S ribosomal subunit, thereby inhibiting bacterial protein synthesis. Tiamulin demonstrates excellent antibacterial activity against Mycoplasma spp. and Brachyspira hyodysenteriae (the causative agent of swine dysentery). It also shows good activity against most Gram-positive bacteria, including Staphylococcus spp. and Streptococcus spp. (except Group D streptococci). While it has some efficacy against Actinobacillus pleuropneumoniae, its activity against most Gram-negative bacteria is weak.
When combined with Chlortetracycline at a ratio of 1:4, this product is effective in treating bacterial enteritis, bacterial pneumonia, and swine dysentery caused by Brachyspira spp. in pigs. It is particularly effective against pneumonia caused by Mycoplasma or mixed infections involving Bordetella bronchiseptica and Pasteurella multocida.
Pharmacokinetics
Tiamulin fumarate is well absorbed following oral administration in pigs. The bioavailability is approximately 85% after a single dose, with peak plasma concentrations reached within 2–4 hours. The drug is widely distributed throughout the body, achieving the highest concentrations in lung tissue. It is extensively metabolized in the body, producing over 20 metabolites, some of which retain antibacterial activity. Metabolites are primarily excreted via bile in the feces, with approximately 30% excreted in the urine.
Drug Interactions
Polyether Ionophores: Concomitant use with polyether antibiotics such as Monensin, Salinomycin, and Narasin interferes with the metabolism of these ionophores. This can lead to toxicity in chickens, characterized by growth retardation, ataxia, paralysis, and even death.
Ribosomal Binding Agents: Concurrent use with other antibiotics that bind to the bacterial 50S ribosomal subunit (e.g., Macrolides, Lincomycin) may result in reduced efficacy due to competition for the same binding site.
Indications
Pleuromutilin antibiotic. Primarily used for the prevention and treatment of Chronic Respiratory Disease (CRD) in chickens, Mycoplasma pneumonia and Actinobacillus pleuropneumoniae in pigs. It is also indicated for swine dysentery and porcine proliferative enteropathy caused by Brachyspira spp.
Dosage and Administration
Route of Administration: Administration in drinking water.
Swine: 0.1–0.13 g per 1 L of water. Administer continuously for 5 days.
Chickens: 0.28–0.56 g per 1 L of water. Administer continuously for 3 days.
Adverse Reactions
When used at recommended doses, skin erythema (redness) may occasionally occur in pigs. Overdose can cause transient salivation, vomiting, and central nervous system depression in pigs.
Precautions
Contraindications: Strictly prohibited for use in combination with polyether ionophores such as Monensin, Salinomycin, and Narasin.
User Safety: Users should avoid contact with eyes and skin.
Withdrawal Period
Swine: 7 days
Chickens: 5 days
Specification
45%
Storage
Store protected from light, in a tightly closed container, in a dry place.
Packaging
100g/bag
R&A Technology Co., Limited
Address: Office 3A-9, 12/F.,Kaiser centre, No.18 CTR Street, Sai，Ying Pun, Hong Kong
Eastern Along Pharmaceutical Co., Ltd.
Address: No. 66, Taoyuan East Road, Songxia Industrial Park, Shilin Town, Nanhai District, Foshan City、
Ramical Pet Health Technology Com.,Ltd
Address: No.10, Hengbao Road, Datang Industrial Park, Sanshui District, Foshan City, Guangdong Province, P.R.C.
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