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FluMeg
Product Name:
Flunixin Meglumine Injection Solution
Active Ingredients
Flunixin Meglumine
Form
A clear, colorless or light yellow liquid.
Pharmacological Action
Pharmacodynamics:
Flunixin meglumine is a powerful cyclooxygenase inhibitor with analgesic, antipyretic, anti-inflammatory, and antirheumatic effects. Its analgesic effect involves blocking the transmission of pain impulses by inhibiting the synthesis of prostaglandins or other substances that increase pain sensitivity. The anti-inflammatory effect on peripheral tissues is associated with the inhibition of cyclooxygenase, reduction of prostaglandin precursors, and suppression of inflammatory response.
Pharmacokinetics:
After a single intravenous injection in cattle (2.2 mg/kg body weight), the half-life is 1–2 hours, and the apparent volume of distribution is 243.18 ± 72.30 ml/kg. After intramuscular injection in pigs (2.2 mg/kg), the half-life is 3–4 hours, the maximum concentration is 2.94 μg/ml, and the time to reach maximum concentration is 0.4 hours. The drug is still detectable in the blood 18 hours post-injection. Bioavailability after neck injection is 87%.
Drug Interactions:
(1) Flunixin meglumine should not be used with other non-steroidal anti-inflammatory drugs (NSAIDs), as this increases the risk of gastrointestinal side effects such as ulcers and bleeding.
(2) Due to its high plasma protein binding, flunixin meglumine may displace or be displaced by other drugs, which can enhance the effects or toxicity of the displaced drugs.
(3) It is used in combination with antibiotics to treat agalactia syndrome in sows.
Indications and Usage
Used to control fever caused by respiratory diseases in cattle, as well as in cases of febrile and inflammatory diseases in animals, and muscle and soft tissue pain.
Administration and Dosage
Intravenously: single dose of 2.2 mg/kg body weight in cattle (no more than 5 days);
Intramuscularly or intravenously: single dose of 2 mg/kg body weight in pigs, 1–2 mg/kg in dogs and cats once or twice daily (no more than 5 days).
Side Effects
Intramuscular injections may cause local irritation. Prolonged use at high doses may cause gastric ulcers and kidney dysfunction.
Precautions
Use with caution in animals with gastrointestinal ulcers.
Do not use with other NSAIDs.
Use in edible tissues of dairy cows is prohibited.
Withdrawal Periods
For pigs – 28 days, for cattle – 24 hours after the last milking.
Specification
100 ml: 5 g (based on C₁₄H₁₁F₃N₂O₂)
Packaging
100 ml/vial × 20 vials/box
Storage Conditions
Store in a tightly closed container, protected from light.
Manufactured and packaged by
Eastern Along Pharmaceutical Co., Ltd.
R&A Technology Co., Limited
Address: Office 3A-9, 12/F.,Kaiser centre, No.18 CTR Street, Sai，Ying Pun, Hong Kong
Eastern Along Pharmaceutical Co., Ltd.
Address: No. 66, Taoyuan East Road, Songxia Industrial Park, Shilin Town, Nanhai District, Foshan City、
Ramical Pet Health Technology Com.,Ltd
Address: No.10, Hengbao Road, Datang Industrial Park, Sanshui District, Foshan City, Guangdong Province, P.R.C.
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