New Gaoli - soluble powder of chloramphenicol hydrochloride and lincomycin hydrochloride

【 Main Ingredients 】 Macromycin Hydrochloride Lincomycin Hydrochloride

【 Appearance 】 This product is a white or off white powder.

Pharmacological effects: Pharmacodynamic analysis shows that erythromycin belongs to the aminoglycoside antibiotic class and has moderate inhibitory effects on various Gram negative bacteria, such as Escherichia coli, Salmonella, Shigella, Proteus, etc. Sensitive to Streptococcus, Pneumococcus, Staphylococcus epidermidis, and certain Mycoplasma species (such as Mycoplasma gallisepticum, Mycoplasma turkey, Mycoplasma synovial fluid, etc.). Not sensitive to grass green streptococcus and Staphylococcus aureus. It is usually resistant to Pseudomonas aeruginosa and spirochetes. Intestinal bacteria are widely resistant to spectinomycin, but do not exhibit cross resistance with streptomycin. Lincomycin has good antibacterial activity against anaerobic bacteria, such as Clostridium, Streptococcus, Streptococcus, Clostridium tetani, Clostridium perfringens, and most actinomycetes. Lincomycin mainly acts on the 50S subunit of bacterial ribosomes, affecting protein synthesis by inhibiting peptide chain elongation.

Pharmacokinetic analysis shows that after oral administration, only 7% of erythromycin is absorbed, but it maintains a high concentration in the gastrointestinal tract. The tissue concentration of the drug is lower than the serum concentration. Not easy to enter cerebrospinal fluid or eyes, with low binding rate to plasma proteins. Most drugs are excreted in their original form through glomerular filtration. Lincomycin has poor absorption when taken orally, with a bioavailability of 30% to 40%. Mixed feeding can reduce its absorption rate and amount. Chickens were given 50mg of this product per kilogram of body weight (dissolved in drinking water) for 7 consecutive days. During the experiment, the concentration of lincomycin in the plasma reached 0.14 µ g/ml, while the concentration of spectinomycin was extremely low, only exceeding 0.1 µ g/ml after 7 days of the experiment.

Drug Interactions

(1) Combined with lincomycin, it can significantly increase the antibacterial activity against mycoplasma and expand the antibacterial spectrum.

(2) The combination of lincomycin and anticholinesterase drugs can reduce the efficacy of the latter.

(3) Combination with erythromycin has an antagonistic effect.

[Function and Use] Antibiotics. Used for Gram negative bacteria, Gram positive bacteria, and mycoplasma infections.

【 Usage and Dosage 】 Calculate based on this product. Mixed drink: Take 2-3.2g of 5-7 day old chicks per 1L of water and use continuously for 3-5 days.

[Adverse reactions] No adverse reactions have been observed when using according to the prescribed dosage.

[Precautions] Only for 5-7 day old chicks.

[Rest period] No need to establish.  

【 Specification 】 100g: 10g of spectinomycin (10 million units) and 5g of lincomycin (calculated based on C18H34N2O6S)

【 Storage 】 Keep tightly sealed and stored in a dry place.

[Packaging] 110g/bag x 40 bags/box

【 Main Ingredients 】 Lincomycin Hydrochloride

【 Appearance 】 This product is a white or off white powder.

[Pharmacological effects] Lincamine antibiotics. Lincomycin belongs to the Lincomamine family and has strong effects on Gram positive bacteria such as Staphylococcus, Streptococcus pyogenes, and Streptococcus pneumoniae. It also has inhibitory effects on anaerobic bacteria such as Clostridium tetani and Clostridium perfringens; The effect on mycoplasma is relatively weak. It also has a certain effect on porcine dysentery spirochetes and Toxoplasma gondii. Gram negative aerobic bacteria are usually insensitive. The absorption rate of animal oral administration is rapid but incomplete, while the bioavailability of pig oral administration is 20% to 50%. Some drugs are metabolized in the liver, and the drug prototype and its metabolites are excreted through bile, urine, and milk.

[Function and Use] Lincolylamine antibiotics. Used to treat Gram positive bacterial infections in pigs and chickens, such as swine dysentery and chicken necrotic enteritis, and can also be used for mycoplasma infections in pigs and chickens.

【 Usage and Dosage 】 Calculate based on this product. Mixed drinking: 0.8-1.4g per 1L of water for pigs, used continuously for 7 days; Chicken 3g, use continuously for 5-10 days.

[Adverse reactions] This product has a neuromuscular blocking effect.

[Precautions] (1) Do not use during the egg laying period of laying hens. (2) Animals that are allergic to this product or have been infected with Candida are prohibited from use.

[Rest period] Pigs and chickens for 5 days.  

[Specification] 5%

【 Storage 】 Seal and store in a dry place.

[Packaging] 110g/bag x 40 bags/box