Auspicin - Flunixin and Metoclopramide Injection

[Main ingredient] Flunixin meglumine

【 Appearance 】 This product is a colorless or light yellow clear liquid.

Pharmacological effects: Flunixin meglumine is a potent cyclooxygenase inhibitor with analgesic, antipyretic, anti-inflammatory, and anti rheumatic effects. The analgesic effect is caused by inhibiting the synthesis of peripheral prostaglandins or their pain sensitizers, or their combined action, thereby blocking the transmission of pain impulses. The anti-inflammatory effect of peripheral tissues may be caused by inhibiting cyclooxygenase, reducing the formation of prostaglandin precursors, and inhibiting other mediators to induce local inflammatory responses.

After a single intravenous injection (2.2mg/kg body weight) in pharmacokinetic cows, the plasma half-life is 1-2 hours and the apparent distribution volume is 243.18 ± 72.30ml/kg. After a single intramuscular injection into pigs (2.2mg/kg body weight), the plasma elimination half-life is 3-4 hours, the peak concentration is 2.94 μ g/ml, and the peak time is 0.4 hours. The drug can still be detected in the blood 18 hours after administration. The apparent distribution volume is 2.0L/kg, and the bioavailability of a single neck injection is 87%.

[Drug Interactions] (1) Flunixin meglumine should not be used together with other nonsteroidal anti-inflammatory drugs, as it can exacerbate toxic side effects on the gastrointestinal tract, such as ulcers, bleeding, etc. (2) Due to the high binding rate of plasma proteins, when used in combination with other drugs, flunixin meglumine may displace other drugs that bind to plasma proteins or be replaced by other drugs, resulting in enhanced effects and even toxicity of the displaced drugs. (3) Combined with antibiotics, it is used as an adjuvant therapy for the absence of milk syndrome in sows.

[Function and Use] Used to control fever caused by respiratory diseases in cows; Used for fever, inflammatory diseases, muscle pain, and soft tissue pain in livestock and small animals.

[Usage and Dosage] Calculated with Flunixin. Intravenous injection: one dose, 2.2mg per 1kg body weight for cows, used continuously for no more than 5 days; Intramuscular and intravenous injection: One dose, 2mg per 1kg body weight for pigs, 1-2mg for dogs and cats, 1-2 times a day, for no more than 5 consecutive days.

【 Adverse reactions 】 Intramuscular injection has a stimulating effect on the local area. Long term high-dose use of this product may lead to gastric ulcers and kidney function damage in animals.

【 Precautions 】 1. Use with caution in livestock with digestive ulcers. 2. Do not use it together with other nonsteroidal anti-inflammatory drugs. 3. It is prohibited to consume edible tissues of cows.

[Rest period] 28 days for pigs; The cow's milk abandonment period is 24 hours.

[Specification] 100ml: 5g calculated based on C14H11F3N2O2

[Storage] Store in a dark and sealed environment.

【 Packaging 】 100ml/bottle